https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44973 n = 257), obtained by using the same DNA chip, were used for validation. Fuzzy clustering was followed by functional annotation of the clusters. Immunohistochemistry was used to confirm transcriptomics results: CD138 and CD20 were used to test for plasma cell and B lymphocyte infiltrations, respectively; MECA79 and CD31 for tertiary lymphoid structures; and UCHL1/PGP9.5 and S100 for neurogenesis. Results: We identified three molecular clusters within TNBC: one molecular apocrine (C1) and two basal-likeenriched (C2 and C3). C2 presented pro-tumorigenic immune response (immune suppressive), high neurogenesis (nerve infiltration), and high biological aggressiveness. In contrast, C3 exhibited adaptive immune response associated with complete B cell differentiation that occurs in tertiary lymphoid structures, and immune checkpoint upregulation. External cohort subtyping by means of the same approach proved the robustness of these results. Furthermore, plasma cell and B lymphocyte infiltrates, tertiary lymphoid structures, and neurogenesis were validated at the protein levels by means of histological evaluation and immunohistochemistry. Conclusion: Our work showed that TNBC can be subcategorized in three different subtypes characterized by marked biological features, some of which could be targeted by specific therapies.]]> Wed 26 Oct 2022 15:01:31 AEDT ]]> Telephone-delivered health behaviour change support for people with a mental health condition: the coaches' perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39767 Wed 22 Jun 2022 11:51:13 AEST ]]> Participants in an online weight loss program can improve diet quality during weight loss: a randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15546 Wed 14 Aug 2024 10:38:25 AEST ]]> Ageing in general practice (AGP) trial: a cluster randomised trial to examine the effectiveness of peer education on GP diagnostic assessment and management of dementia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15187 Wed 14 Aug 2024 10:31:49 AEST ]]> Impact of behavioural risk factors on death within 10 years for women and men in their 70s: absolute risk charts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15184 Wed 14 Aug 2024 10:23:08 AEST ]]> Is minimally invasive parathyroid surgery an option for patients with gestational primary hyperparathyroidism? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14816 Wed 11 Apr 2018 17:21:40 AEST ]]> Can personal qualities of medical students predict in-course examination success and professional behaviour? An exploratory prospective cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15174 Wed 11 Apr 2018 17:19:04 AEST ]]> Comparative in-vivo toxicity of venoms from South Asian hump-nosed pit vipers (Viperidae: Crotalinae: Hypnale) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15146 Wed 11 Apr 2018 17:11:07 AEST ]]> A randomised controlled trial and mediation analysis of the 'Healthy Habits', telephone-based dietary intervention for preschool children https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15732 Wed 11 Apr 2018 17:05:14 AEST ]]> Sustaining modified behaviours learnt in a diabetes prevention program in regional Australia: the role of social context https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15203 Wed 11 Apr 2018 16:56:38 AEST ]]> Tailoring a response to youth binge drinking in an Aboriginal Australian community: a grounded theory study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14758 Wed 11 Apr 2018 16:48:57 AEST ]]> Growing old before growing rich: inequality in health service utilization among the mid-aged and elderly in Gansu and Zhejiang Provinces, China https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15176 Wed 11 Apr 2018 16:44:39 AEST ]]> Empirical evidence of the continuing improvement in cost efficiency of an endoscopic surveillance programme for gastric cancer in Singapore from 2004 to 2010 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14768 Wed 11 Apr 2018 16:32:20 AEST ]]> Costs of medicines and health care: a concern for Australian women across the ages https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14771 Wed 11 Apr 2018 16:01:48 AEST ]]> A cluster-randomized controlled trial of strategies to increase adolescents' physical activity and motivation during physical education lessons: the Motivating Active Learning in Physical Education (MALP) trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15173 Wed 11 Apr 2018 15:53:51 AEST ]]> Prevalence and correlates of depression among Australian women: a systematic literature review, January 1999-January 2010 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15370 Wed 11 Apr 2018 15:40:17 AEST ]]> Using administrative health data to describe colorectal and lung cancer care in New South Wales, Australia: a validation study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15194 Wed 11 Apr 2018 15:37:49 AEST ]]> A phase II clinical trial of a dental health education program delivered by aboriginal health workers to prevent early childhood caries https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15145 Wed 11 Apr 2018 15:36:10 AEST ]]> Exploratory randomized controlled trial evaluating the impact of a waiting list control design https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14829 Wed 11 Apr 2018 15:21:10 AEST ]]> The effects of a rhythm and music-based therapy program and therapeutic riding in late recovery phase following stroke: a study protocol for a three-armed randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15202 Wed 11 Apr 2018 15:20:44 AEST ]]> Continuing difficulties in interpreting CNV data: lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14804 Wed 11 Apr 2018 14:46:12 AEST ]]> Musculoskeletal disorders and symptom severity among Australian dental hygienists https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14775 Wed 11 Apr 2018 14:43:05 AEST ]]> Sociodemographic and health-related predictors of self-reported mammogram, faecal occult blood test and prostate specific antigen test use in a large Australian study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14762 Wed 11 Apr 2018 14:39:01 AEST ]]> Embedding chiropractic in indigenous health care organisations: applying the normalisation process model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15143 Wed 11 Apr 2018 14:34:26 AEST ]]> STaRRRT: a table of short tandem repeats in regulatory regions of the human genome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14811 Wed 11 Apr 2018 14:25:00 AEST ]]> Move more for life: the protocol for a randomised efficacy trial of a tailored-print physical activity intervention for post-treatment breast cancer survivors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15193 Wed 11 Apr 2018 14:08:30 AEST ]]> Parent attitudes, family dynamics and adolescent drinking: qualitative study of the Australian parenting guidelines for adolescent alcohol use https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15171 Wed 11 Apr 2018 14:00:48 AEST ]]> A retrospective analysis of maternal and neonatal mortality at a teaching and referral hospital in Kenya https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14749 Wed 11 Apr 2018 13:58:15 AEST ]]> Theory-and evidence-based development and process evaluation of the Move More for Life program: a tailored-print intervention designed to promote physical activity among post-treatment breast cancer survivors https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14799 Wed 11 Apr 2018 13:55:47 AEST ]]> Generalist solutions to complex problems: generating practice-based evidence - the example of managing multi-morbidity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14772 2 diseases) is a product of the design of health care systems which define health care need on the basis of disease status. So does the solution lie in an alternative model of healthcare? Discussion: Strengthening generalist practice has been proposed as part of the solution to tackling multi-morbidity. Generalism is a professional philosophy of practice, deeply known to many practitioners, and described as expertise in whole person medicine. But generalism lacks the evidence base needed by policy makers and planners to support service redesign. The challenge is to fill this practice-research gap in order to critically explore if and when generalist care offers a robust alternative to management of this complex problem. We need practice-based evidence to fill this gap. By recognising generalist practice as a ‘complex intervention’ (intervening in a complex system), we outline an approach to evaluate impact using action-research principles. We highlight the implications for those who both commission and undertake research in order to tackle this problem. Summary: Answers to the complex problem of multi-morbidity won’t come from doing more of the same. We need to change systems of care, and so the systems for generating evidence to support that care. This paper contributes to that work through outlining a process for generating practice-based evidence of generalist solutions to the complex problem of person-centred care for people with multi-morbidity.]]> Wed 11 Apr 2018 13:41:48 AEST ]]> Do couple-based interventions make a difference for couples affected by cancer?: A systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15204 Wed 11 Apr 2018 13:36:37 AEST ]]> Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2013 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14827 Wed 11 Apr 2018 13:36:21 AEST ]]> Can selenium levels act as a marker of colorectal cancer risk? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14831 Wed 11 Apr 2018 13:24:36 AEST ]]> Retention of allied health professionals in rural New South Wales: a thematic analysis of focus group discussions https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15183 Wed 11 Apr 2018 13:22:59 AEST ]]> An olfactory 'stress test' may detect preclinical Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15148 Wed 11 Apr 2018 13:22:28 AEST ]]> Socioeconomic inequality in domains of health: results from the World Health Surveys https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15149 Wed 11 Apr 2018 13:10:08 AEST ]]> Increasing the use of preventative health services to promote healthy eating, physical activity and weight management: the acceptability and potential effectiveness of a proactive telemarketing approach https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15191 Wed 11 Apr 2018 13:02:21 AEST ]]> Potential for the Australian and New Zealand paediatric intensive care registry to enhance acute flaccid paralysis surveillance in Australia: a data-linkage study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14803 Wed 11 Apr 2018 13:00:19 AEST ]]> Local level epidemiological analysis of TB in people from a high incidence country of birth https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14752 100/100,000. Those notified with TB in the nine areas also had a shorter length of stay in Australia than the rest of the state. The areas with higher TB notification rates were all in the capital city, Sydney. Among LGAs with higher TB notification rates, four had higher rates in both people with a high-incidence country of birth and people not born in a high-incidence country. The age distribution of the HIC population was similar across all areas, and the highest differential in TB rates across areas was in the 5–19 years age group. Conclusions: Analysing local area TB rates and possible explanatory variables can provide useful insights into the epidemiology of TB. TB notification rates that take country of birth in local areas into account could enable health services to strategically target TB control measures.]]> Wed 11 Apr 2018 12:55:52 AEST ]]> Energy status of ripening and postharvest senescent fruit of litchi (Litchi chinensis Sonn.) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14751 Wed 11 Apr 2018 12:47:37 AEST ]]> A systematic review of the impact of stigma and nihilism on lung cancer outcomes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15201 Wed 11 Apr 2018 12:36:30 AEST ]]> A qualitative study into the use of formal services for dementia by carers from culturally and linguistically diverse (CALD) communities https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15170 Wed 11 Apr 2018 12:34:47 AEST ]]> Development and reliability testing of a self-report instrument to measure the office layout as a correlate of occupational sitting https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14809 Wed 11 Apr 2018 12:33:26 AEST ]]> Relationship between central and peripheral fatty acids in humans https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14801 Wed 11 Apr 2018 12:26:36 AEST ]]> Pertussis vaccination in child care workers: room for improvement in coverage, policy and practice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15151 Wed 11 Apr 2018 12:07:56 AEST ]]> Can exercise ameliorate treatment toxicity during the initial phase of testosterone deprivation in prostate cancer patients? Is this more effective than delayed rehabilitation? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15188 Wed 11 Apr 2018 11:51:25 AEST ]]> The quality of the evidence base for clinical pathway effectiveness: room for improvement in the design of evaluation trials https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15185 Wed 11 Apr 2018 11:47:51 AEST ]]> Non-invasive detection of microvascular changes in a paediatric and adolescent population with type 1 diabetes: a pilot cross-sectional study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14765 Wed 11 Apr 2018 11:44:11 AEST ]]> Alternative mRNA fates identified in microRNA-associated transcriptome analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15192 Wed 11 Apr 2018 11:39:00 AEST ]]> Acceptance and commitment therapy for anxious children and adolescents: study protocol for a randomized controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14770 Wed 11 Apr 2018 11:35:47 AEST ]]> Fundamental movement skills and physical activity among children living in low-income communities: a cross-sectional study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15553 Wed 11 Apr 2018 11:33:58 AEST ]]> Medicines and the media: news reports of medicines recommended for government reimbursement in Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14800 = 20 news reports (total 2350 stories); nine of these cost more than AU$10,000 per course or year of treatment. For these 18 medicines, 31% of stories appeared in the six months prior to the PBAC meeting, 14% in the meeting month and 33% in the six months post-meeting. 38% of the stories had >= 3 medicine mentions, 37% referred to the PBS, 24% to cost to the patient, and 9% cost to Government. There was active patient lobby group campaigning in support of listing of infliximab and pemetrexed; the stories for ADHD were often more negative, referring to the dangers of the medicines and sometimes questioning the appropriateness of treatment and public subsidy. There was little discussion of the PBAC's evidence-based decision-making processes. Conclusions: While there was no general trend to increased news reporting associated with PBAC meetings, some drugs did attract media attention. With more new and expensive drugs, decisions on public funding will become increasingly difficult. The media have an important role in enhancing public understanding of the issues around resource allocation. Specialist journalists, guidelines and checklists may help reporting.]]> Wed 11 Apr 2018 11:22:54 AEST ]]> Efficacy of acupuncture for chronic knee pain: protocol for a randomised controlled trial using a Zelen design https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15154 Wed 11 Apr 2018 11:20:36 AEST ]]> Retention of the rural allied health workforce in New South Wales: a comparison of public and private practitioners https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14797 Wed 11 Apr 2018 11:17:18 AEST ]]> Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15159 Wed 11 Apr 2018 11:13:56 AEST ]]> Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14773 Wed 11 Apr 2018 11:04:31 AEST ]]> A cross-sectional study assessing the self-reported weight loss strategies used by adult Australian general practice patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15158 Wed 11 Apr 2018 11:03:03 AEST ]]> A cluster randomised trial of a school-based resilience intervention to decrease tobacco, alcohol and illicit drug use in secondary school students: study protocol https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15190 Wed 11 Apr 2018 11:02:11 AEST ]]> Breakingtheice: a protocol for a randomised controlled trial of an internet-based intervention addressing amphetamine-type stimulant use https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15175 Wed 11 Apr 2018 11:00:08 AEST ]]> Disparities in reported psychosocial assessment across public and private maternity settings: a national survey of women in Australia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14767 Wed 11 Apr 2018 10:55:28 AEST ]]> A holistic high-throughput screening framework for biofuel feedstock assessment that characterises variations in soluble sugars and cell wall composition in Sorghum bicolor https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14798 Wed 11 Apr 2018 10:49:42 AEST ]]> Study protocol: the registrar clinical encounters in training (ReCEnT) study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15157 Wed 11 Apr 2018 10:46:34 AEST ]]> A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15172 Wed 11 Apr 2018 10:45:36 AEST ]]> An investigation of factors associated with the health and well-being of HIV-infected or HIV-affected older people in rural South Africa https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15144 Wed 11 Apr 2018 10:44:00 AEST ]]> Associations between program outcomes and adherence to social cognitive theory tasks: process evaluation of the SHED-IT community weight loss trial for men https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15547 Wed 11 Apr 2018 10:43:23 AEST ]]> Efficacy of manual therapy treatments for people with cervicogenic dizziness and pain: protocol of a randomised controlled trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15155 Wed 11 Apr 2018 10:31:20 AEST ]]> Wearing face masks in public during the influenza season may reflect other positive hygiene practices in Japan https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15153 Wed 11 Apr 2018 10:24:47 AEST ]]> Poor food and nutrient intake among Indigenous and non-Indigenous rural Australian children https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15182 Wed 11 Apr 2018 10:23:43 AEST ]]> How health professionals conceive and construct interprofessional practice in rural settings: a qualitative study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14813 Wed 11 Apr 2018 10:21:18 AEST ]]> Rationale and study protocol of the EASY Minds (encouraging activity to stimulate young minds) program: cluster randomized controlled trial of a primary school-based physical activity integration program for mathematics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15545 Wed 11 Apr 2018 10:07:00 AEST ]]> A qualitative study of stakeholder views of the conditions for and outcomes of successful clinical networks https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15205 Wed 11 Apr 2018 09:45:15 AEST ]]> A re-evaluation of the scratch test for locating the liver edge https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14769 Wed 11 Apr 2018 09:39:53 AEST ]]> Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14826 Wed 11 Apr 2018 09:25:23 AEST ]]> A systematic review of suicide prevention interventions targeting indigenous peoples in Australia, United States, Canada and New Zealand https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14825 Wed 11 Apr 2018 09:17:44 AEST ]]> Impact of a population based intervention to increase the adoption of multiple physical activity practices in centre based childcare services: a quasi experimental, effectiveness study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15532 Tue 24 Aug 2021 14:39:28 AEST ]]> Validity of a self-report survey tool measuring the nutrition and physical activity environment of primary schools https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15510 Tue 24 Aug 2021 14:35:07 AEST ]]> A cluster randomised trial of a school-based intervention to prevent decline in adolescent physical activity levels: study protocol for the 'Physical Activity 4 Everyone' trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15512 Tue 24 Aug 2021 14:34:54 AEST ]]> The impact of chelation compliance in health outcome and health related quality of life in thalassaemia patients: a systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55363 Tue 21 May 2024 09:36:32 AEST ]]> Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41899 PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods: Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included, providing data on 79,578 participants. Results were scaled to a one mmol/L lower LDL-C concentration. Results: The PCSK9 GS (comprising 4 SNPs) associations with plasma lipid and apolipoprotein levels were consistent in direction with treatment effects. The GS odds ratio (OR) for myocardial infarction (MI) was 0.53 (95% CI 0.42; 0.68), compared to a PCSK9 inhibitor effect of 0.90 (95% CI 0.86; 0.93). For ischemic stroke ORs were 0.84 (95% CI 0.57; 1.22) for the GS, compared to 0.85 (95% CI 0.78; 0.93) in the drug trials. ORs with type 2 diabetes mellitus (T2DM) were 1.29 (95% CI 1.11; 1.50) for the GS, as compared to 1.00 (95% CI 0.96; 1.04) for incident T2DM in PCSK9 inhibitor trials. No genetic associations were observed for cancer, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, or Alzheimer’s disease – outcomes for which large-scale trial data were unavailable. Conclusions: Genetic variation at the PCSK9 locus recapitulates the effects of therapeutic inhibition of PCSK9 on major blood lipid fractions and MI. While indicating an increased risk of T2DM, no other possible safety concerns were shown; although precision was moderate.]]> Tue 16 Aug 2022 08:27:58 AEST ]]> The impact of a regionally based translational cancer research collaborative in Australia using the FAIT methodology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54997 Tue 13 Aug 2024 10:14:48 AEST ]]> An initial typology of approaches used by policy and practice agencies to achieve sustained implementation of interventions to improve health. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54973 Tue 13 Aug 2024 09:44:50 AEST ]]> Employment and retirement impacts on health and wellbeing among a sample of rural Australians https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39122 Tue 10 May 2022 17:28:34 AEST ]]> Effectiveness of interventions to improve rates of intravenous thrombolysis using behaviour change wheel functions: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41188 75%) was observed for all the pooled analyses. Publication bias was also identified. Conclusion: There was no evidence for preferring one type of behaviour change intervention strategy, nor for including multiple strategies in improving thrombolysis rates. However, the study results should be interpreted with caution, as they display high heterogeneity and publication bias.]]> Thu 28 Jul 2022 11:05:36 AEST ]]> Gene set enrichment analysis of RNA-Seq data: integrating differential expression and splicing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14818 Thu 12 Apr 2018 13:24:24 AEST ]]> Diagnosis of transition zone prostate cancer by multiparametric MRI: added value of MR spectroscopic imaging with sLASER volume selection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40626 Thu 11 Aug 2022 11:20:50 AEST ]]> Depot buprenorphine as an opioid agonist therapy in New South Wales correctional centres: a costing model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52250 Thu 05 Oct 2023 14:07:25 AEDT ]]> Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55377 Mon 19 Aug 2024 18:23:34 AEST ]]> Common musculoskeletal impairments in postpartum runners: an international Delphi study. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41098 Fri 22 Jul 2022 18:14:15 AEST ]]> The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52684 Fri 20 Oct 2023 09:58:07 AEDT ]]> Identifying essential implementation strategies: a mixed methods process evaluation of a multi-strategy policy implementation intervention for schools https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51750 Fri 15 Sep 2023 18:22:11 AEST ]]> Availability and readiness of healthcare facilities and their effects on antenatal care services uptake in Bangladesh https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55281 Fri 10 May 2024 16:13:47 AEST ]]> Identification and evaluation of risk of generalizability biases in pilot versus efficacy/effectiveness trials: A systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41558 Fri 05 Aug 2022 14:31:00 AEST ]]> Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41557 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55–100 mmHg) patients (P = 0.47). Conclusions; Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort.]]> Fri 05 Aug 2022 14:30:30 AEST ]]>